DCLK1 is a microtubule-associated protein that marks cancer cells that have obtained tumor stemness properties in many solid tumors.

It is a master regulatory protein that drives tumorigenesis, EMT, and when elevated is associated with poor overall survival. Recently it has been associated with immunosuppressive features in several gastrointestinal cancers.

Several studies have reported that downregulation of DCLK1 inhibits invasion/migration and EMT in solid tumor cancers (pancreas, colon, kidney, ovarian, and breast). These data provide the fundamental rationale for COARE’s developmental therapeutic program targeting DCLK1-expressing cells for the treatment of epithelial solid tumor cancers.