Functional implication of Dclk1 and Dclk1-expressing cells in cancer
… in understanding of the importance of Dclk1 function in tumorigenesis and cancer. … pancreatic cancer cells with reduced Dclk1 gene expression, and demonstrated that Dclk1 regulated …
Link: https://www.tandfonline.com/doi/abs/10.1080/21541248.2016.1208792
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
… In this study, we investigated whether DCLK1 expression is altered in human colorectal cancer and its clinical significance. We observed that DCLK1 expression was not only …
Link: https://link.springer.com/article/10.1007/s00432-016-2218-0
DCLK1 Plays a Metastatic‐Promoting Role in Human Breast Cancer Cells
… to knock out DCLK1 in breast cancer cell line BT474… DCLK1 at a higher level, and stably overexpressed DCLK1 in another breast cancer cell line, T47D, that basically expresses DCLK1 …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/1061979
Pleiotropic effects of DCLK1 in cancer and cancer stem cells
… Moreover, this review summarizes the effect of upregulated DCLK1 in several cancers … of DCLK1 by the use of small inhibitory molecules along with exosomes to target DCLK1, which …
Link: https://www.frontiersin.org/articles/10.3389/fmolb.2022.965730/full
Research progress of DCLK1 inhibitors as cancer therapeutics
… DCLK1 has the potential to inhibit cancer cell growth. Here, we review the evidence for DCLK1 as a prospective cancer … and mutational status in human cancers. We further discuss the …
Link: https://www.ingentaconnect.com/content/ben/cmc/2022/00000029/00000013/art00004
DCLK1 plays an important role in colorectal cancer tumorgenesis through the regulation of miR-200c
… Silencing of DCLK1 significantly inhibited cell migration, invasion, and sphere-forming … DCLK1 expression. Overall, our data demonstrated that DCLK1 plays an important role in cancer …
Link: https://www.sciencedirect.com/science/article/pii/S0753332218311685
DCLK1 promotes malignant progression of breast cancer by regulating Wnt/β-Catenin signaling pathway.
… , we predict whether DCLK1 can be involved in the process of breast cancer cell proliferation and metastasis through the targeted regulation of the Wnt/β-catenin signal pathway. …
Link: https://www.europeanreview.org/wp/wp-content/uploads/9489-9498.pdf
DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer
… of DCLK1 in colon cancer cells (65). In addition, crocetinic acid targets DCLK1 in cancer cells by inhibiting the hedgehog signaling pathway in pancreatic cancer cells (65). …
Link: https://www.spandidos-publications.com/10.3892/ol.2021.13111
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
… cancer In pancreatic and colorectal cancer cells, we have previously demonstrated that DCLK1 … siRNA-mediated knockdown of DCLK1 resulted in downregulation of let-7a downstream …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073940
Cancer stem cell marker DCLK1 correlates with tumorigenic immune infiltrates in the colon and gastric adenocarcinoma microenvironments
… cancers [41]. To explore the potential of using DCLK1 as a prognostic biomarker in GI cancers… High DCLK1 expression in tumor tissues predicted poor disease-specific survival (DSS) in …
Link: https://www.mdpi.com/2072-6694/12/2/274
The essential role of DCLK1 in pathogenesis, diagnostic procedures and prognostic stratification of colorectal cancer
… to DCLK1 and DCLK1-target therapy by colorectal cancer, … Implications of DCLK1 Overexpression in Colorectal Cancer’. … with regard to DCLK1 in colorectal cancer, for formulating …
Link: https://ar.iiarjournals.org/content/39/6/2689.short
Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent …
… Here, we investigated whether DCLK1 negatively regulates miR-143/145 in liver cancer. mRNA isolated from siRNA-treated tumors were analyzed for miR-143 and miR-145. We …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741924/
Regulatory roles of Dclk1 in epithelial mesenchymal transition and cancer stem cells
… of cancer. We will highlight the functional activity of DCLK1 in supporting EMT and cancer … us to a better understanding of DCLK1 expression in cancer development and progression, …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913783/
… DCLK1) regulates B cell-specific moloney murine leukemia virus insertion site 1 (Bmi-1) and is associated with metastasis and prognosis in pancreatic cancer
… Knockdown of DCLK1 markedly suppressed cell growth in vitro and in vivo and also … of pancreatic cancer cells. Furthermore, we found that DCLK1 silencing could inhibit EMT in cancer …
Link: https://karger.com/cpb/article/51/1/262/75450
Survival of patients with gastrointestinal cancers can be predicted by a surrogate microRNA signature for cancer stem–like cells marked by DCLK1 kinase
… the survival of patients with these cancers. Moreover, we … DCLK1 surrogate biomarker. Our findings greatly strengthen the clinical significance for DCLK1 expression across GI cancers. …
Link: https://aacrjournals.org/cancerres/article-abstract/76/14/4090/613631
Targeting DCLK1 overcomes 5‐fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β‐catenin pathway‐mediated cancer stemness
… DCLK1 promoted cancer stemness, and DCLK1 positively regulated β-catenin signalling via CCAR1, we speculated that DCLK1 maintained cancer … (IWR-1-endo), DCLK1-mediated …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ctm2.743
DCLK1 inhibition attenuates tumorigenesis and improves chemosensitivity in esophageal squamous cell carcinoma by inhibiting β-catenin/c-Myc signaling
… and colorectal cancers are closely associated with DCLK1 + cancer stem cells [2, 22]. … of colorectal cancer cells [14]. High expression of DCLK1 in human pancreatic cancer is closely …
Link: https://link.springer.com/article/10.1007/s00424-020-02415-z
LncRNA SNHG1 promotes EMT process in gastric cancer cells through regulation of the miR-15b/DCLK1/Notch1 axis
… cancer cells via the miR-15b-regulated DCLK1/Notch1 axis. Therefore, a series of experiments was used to verify whether DCLK1, … to determine the role of DCLK1, miR15b and lncRNA …
Link: https://link.springer.com/article/10.1186/s12876-020-01272-5
Dominant expression of DCLK1 in human pancreatic cancer stem cells accelerates tumor invasion and metastasis
… -lived DCLK1-positive cells and initiation of colon cancer [23]. … in mice that express DCLK1 contain morphologically and … pancreatic cancers, our studies revealed that DCLK1 is …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146564
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
… to target Dclk1 as a treatment strategy for colorectal cancer. … is less effective than DCLK1 knockdown in inhibiting cancer cells’ … Dclk1 can regulate multiple signaling pathways for cancer …
Link: https://link.springer.com/article/10.1186/s12943-017-0594-y
DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
… The high rate of cancer metastasis is a major issue in managing CRC. To unravel relevant … of DCLK1 in CRC, we conducted a series of assays with the DCLK1-silenced colon cancer …
Link: https://academic.oup.com/carcin/article-abstract/41/3/303/5575723
Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications
… DCLK1-gene remains unchanged and DCLK1-L, originating from 5′(α)-promoter, is expressed. We hypothesized that elevated levels of DCLK1… -transcripts of DCLK1 (termed DCLK1-S…
Link: https://www.nature.com/articles/srep14983
DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner
… DCLK1 and miR-137 and miR-15a levels in colorectal cancer. A total of 222 samples, including 181 colorectal cancer … , were stained for DCLK1 expression using immunohistochemistry. …
Link: https://link.springer.com/article/10.1007/s10238-020-00665-w
Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
… We previously reported that DCLK1 is overexpressed in RCC compared to … DCLK1's expression in kidney cancers, we analyzed The Cancer Genome Atlas (TCGA) PAN-CANCER RNA-…
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31400
MicroRNA-195 suppresses the progression of pancreatic cancer by targeting DCLK1
… However, the roles of DCLK1 in cancer and miRNAs that directly regulate DCLK1 have not … -195 on inhibiting DCLK1 and to clarify the regulating mechanism of miR-195-DCLK1 in PC …
Link: https://karger.com/cpb/article/44/5/1867/73532
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
… We induced overexpression of DCLK1 and inhibited DCLK1 (using inhibitors LRRK2-IN-1, … if DCLK1 and PD-L1 were strongly correlated. Mechanistically, we also explored if DCLK1 …
Link: https://www.sciencedirect.com/science/article/pii/S0024320519310781
Dclk1 inhibition cancels 5-FU-induced cell-cycle arrest and decreases cell survival in colorectal cancer
… pancreatic cancer cells with gemcitabine (GEM) and a Dclk1 … enhanced by Dclk1 inhibition in the pancreatic cancer cells (16… be enhanced by Dclk1 inhibition in colorectal cancer cells. …
Link: https://ar.iiarjournals.org/content/38/11/6225.short
Inhibition of DCLK1 with DCLK1-IN-1 suppresses renal cell carcinoma invasion and stemness and promotes cytotoxic T-cell-mediated anti-tumor immunity
… Previous findings demonstrate that doublecortin-like kinase 1 (DCLK1) … DCLK1-IN-1 strongly inhibits DCLK1 phosphorylation and downregulates pluripotency factors and cancer stem …
Link: https://www.mdpi.com/2072-6694/13/22/5729
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
… As we have seen in other cancers and cancer cell lines [12], knockdown of DCLK1 reduced the expression of stem cell pluripotency factors MYC, NANOG, POU5F1/OCT4, and SOX2 in …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385845/
Enhancement of sensitivity to chemo/radiation therapy by using miR-15b against DCLK1 in colorectal cancer
… between DCLK1 expression in post-nRT rectal cancer and … role for DCLK1 in tumor initiation, the DCLK1+ and DCLK1− cells … Purified DCLK1+ but not DCLK1− cells were able to form …
Link: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30438-7