DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
… The high rate of cancer metastasis is a major issue in managing CRC. To unravel relevant … of DCLK1 in CRC, we conducted a series of assays with the DCLK1-silenced colon cancer …
Link: https://academic.oup.com/carcin/article-abstract/41/3/303/5575723
Epigenetic changes and alternate promoter usage by human colon cancers for expressing DCLK1-isoforms: Clinical Implications
… DCLK1-gene remains unchanged and DCLK1-L, originating from 5′(α)-promoter, is expressed. We hypothesized that elevated levels of DCLK1… -transcripts of DCLK1 (termed DCLK1-S…
Link: https://www.nature.com/articles/srep14983
DCLK1, a promising colorectal cancer stem cell marker, regulates tumor progression and invasion through miR-137 and miR-15a dependent manner
… DCLK1 and miR-137 and miR-15a levels in colorectal cancer. A total of 222 samples, including 181 colorectal cancer … , were stained for DCLK1 expression using immunohistochemistry. …
Link: https://link.springer.com/article/10.1007/s10238-020-00665-w
Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
… We previously reported that DCLK1 is overexpressed in RCC compared to … DCLK1's expression in kidney cancers, we analyzed The Cancer Genome Atlas (TCGA) PAN-CANCER RNA-…
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31400
MicroRNA-195 suppresses the progression of pancreatic cancer by targeting DCLK1
… However, the roles of DCLK1 in cancer and miRNAs that directly regulate DCLK1 have not … -195 on inhibiting DCLK1 and to clarify the regulating mechanism of miR-195-DCLK1 in PC …
Link: https://karger.com/cpb/article/44/5/1867/73532
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
… We induced overexpression of DCLK1 and inhibited DCLK1 (using inhibitors LRRK2-IN-1, … if DCLK1 and PD-L1 were strongly correlated. Mechanistically, we also explored if DCLK1 …
Link: https://www.sciencedirect.com/science/article/pii/S0024320519310781
Dclk1 inhibition cancels 5-FU-induced cell-cycle arrest and decreases cell survival in colorectal cancer
… pancreatic cancer cells with gemcitabine (GEM) and a Dclk1 … enhanced by Dclk1 inhibition in the pancreatic cancer cells (16… be enhanced by Dclk1 inhibition in colorectal cancer cells. …
Link: https://ar.iiarjournals.org/content/38/11/6225.short
Inhibition of DCLK1 with DCLK1-IN-1 suppresses renal cell carcinoma invasion and stemness and promotes cytotoxic T-cell-mediated anti-tumor immunity
… Previous findings demonstrate that doublecortin-like kinase 1 (DCLK1) … DCLK1-IN-1 strongly inhibits DCLK1 phosphorylation and downregulates pluripotency factors and cancer stem …
Link: https://www.mdpi.com/2072-6694/13/22/5729
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
… To consolidate our understanding of kinase activity dependent biological functions in cancer, a selective DCLK1 inhibitor, DCLK1-IN-1 was used. Initially, DCLK1-IN-1 10 was …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330537/
DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma
… As we have seen in other cancers and cancer cell lines [12], knockdown of DCLK1 reduced the expression of stem cell pluripotency factors MYC, NANOG, POU5F1/OCT4, and SOX2 in …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385845/