Pleiotropic effects of DCLK1 in cancer and cancer stem cells
… Moreover, this review summarizes the effect of upregulated DCLK1 in several cancers … of DCLK1 by the use of small inhibitory molecules along with exosomes to target DCLK1, which …
Link: https://www.frontiersin.org/journals/molecular-biosciences/articles/10.3389/fmolb.2022.965730/full
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
… In this study, we investigated whether DCLK1 expression is altered in human colorectal cancer and its clinical significance. We observed that DCLK1 expression was not only …
Link: https://link.springer.com/article/10.1007/s00432-016-2218-0
Functional implication of Dclk1 and Dclk1-expressing cells in cancer
… in understanding of the importance of Dclk1 function in tumorigenesis and cancer. … pancreatic cancer cells with reduced Dclk1 gene expression, and demonstrated that Dclk1 regulated …
Link: https://www.tandfonline.com/doi/abs/10.1080/21541248.2016.1208792
DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer
… of DCLK1 in colon cancer cells (65). In addition, crocetinic acid targets DCLK1 in cancer cells by inhibiting the hedgehog signaling pathway in pancreatic cancer cells (65). …
Link: https://www.spandidos-publications.com/10.3892/ol.2021.13111
Regulatory roles of Dclk1 in epithelial mesenchymal transition and cancer stem cells
… of cancer. We will highlight the functional activity of DCLK1 in supporting EMT and cancer … us to a better understanding of DCLK1 expression in cancer development and progression, …
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4913783/
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression
… results point toward cancer cell–intrinsic and –extrinsic functions for the DCLK1 kinase activity through the induction of cancer cell EMT leading to the mobilization of cancer cells into …
Link: https://www.science.org/doi/abs/10.1126/scisignal.abq4888
DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target
… cancer progression. This review comprehensively examines the multifaceted roles of DCLK1 in GI cancers, … inflammatory states, and contributions to cancer progression and metastasis. …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.35365
DCLK1 plays a metastatic‐promoting role in human breast cancer cells
… to knock out DCLK1 in breast cancer cell line BT474… DCLK1 at a higher level, and stably overexpressed DCLK1 in another breast cancer cell line, T47D, that basically expresses DCLK1 …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/1061979
Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: a systematic review and meta-analysis
… -S isoform; and (iii) studies based on using antibodies could detect the sequence homology epitopes of both DCLK1-L and DCLK1-S isoforms, known as anti-DCLK1-L/S antibodies in …
Link: https://link.springer.com/article/10.1186/s12935-022-02632-9
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer
… cancers, it is not clear whether they emerge during early or late stages of tumorigenesis. Using mouse models and human pancreatic cancer cell … and cancer stem cell–like properties. …
Link: https://www.sciencedirect.com/science/article/pii/S001650851301411X
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
… cancer In pancreatic and colorectal cancer cells, we have previously demonstrated that DCLK1 … siRNA-mediated knockdown of DCLK1 resulted in downregulation of let-7a downstream …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073940
Dominant expression of DCLK1 in human pancreatic cancer stem cells accelerates tumor invasion and metastasis
… -lived DCLK1-positive cells and initiation of colon cancer [23]. … in mice that express DCLK1 contain morphologically and … pancreatic cancers, our studies revealed that DCLK1 is …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146564
Role of DCLK1 in oncogenic signaling
… inflammation induced by dextran sodium sulfate is sufficient to initiate colon cancer in Dclk1-Cre/Apcflox/flox (Dclk1-Cre/Apcflox/flox transgenic mice featuring knocking out APC gene in …
Link: https://www.spandidos-publications.com/10.3892/ijo.2022.5427
Cancer stem cell marker DCLK1 correlates with tumorigenic immune infiltrates in the colon and gastric adenocarcinoma microenvironments
… cancers [41]. To explore the potential of using DCLK1 as a prognostic biomarker in GI cancers… High DCLK1 expression in tumor tissues predicted poor disease-specific survival (DSS) in …
Link: https://www.mdpi.com/2072-6694/12/2/274
Targeting DCLK1 overcomes 5‐fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β‐catenin pathway‐mediated cancer stemness
… DCLK1 promoted cancer stemness, and DCLK1 positively regulated β-catenin signalling via CCAR1, we speculated that DCLK1 maintained cancer … (IWR-1-endo), DCLK1-mediated …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ctm2.743
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
… Therefore, we sought to understand if DCLK1 could positively regulate the expression of PD-L1 in pancreatic cancer cells. Furthermore, we examined if DCLK1 highly correlated with …
Link: https://www.sciencedirect.com/science/article/pii/S0024320519310781
DCLK1 promotes malignant progression of breast cancer by regulating Wnt/β-Catenin signaling pathway.
… , we predict whether DCLK1 can be involved in the process of breast cancer cell proliferation and metastasis through the targeted regulation of the Wnt/β-catenin signal pathway. …
Link: https://www.europeanreview.org/wp/wp-content/uploads/9489-9498.pdf
DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
… The high rate of cancer metastasis is a major issue in managing CRC. To unravel relevant … of DCLK1 in CRC, we conducted a series of assays with the DCLK1-silenced colon cancer …
Link: https://academic.oup.com/carcin/article-abstract/41/3/303/5575723
DCLK1 autoinhibition and activation in tumorigenesis
… Somatic DCLK1 cancer mutants display elevated kinase activity To explore the impact of DCLK1 somatic mutations in human cancers, we interrogated the COSMIC database and found …
Link: https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00116-8
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
… To consolidate our understanding of kinase activity dependent biological functions in cancer, a selective DCLK1 inhibitor, DCLK1-IN-1 was used. Initially, DCLK1-IN-1 10 was …
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC9330537/
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