Functional implication of Dclk1 and Dclk1-expressing cells in cancer
… in understanding of the importance of Dclk1 function in tumorigenesis and cancer. … pancreatic cancer cells with reduced Dclk1 gene expression, and demonstrated that Dclk1 regulated …
Link: https://www.tandfonline.com/doi/abs/10.1080/21541248.2016.1208792
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
… In this study, we investigated whether DCLK1 expression is altered in human colorectal cancer and its clinical significance. We observed that DCLK1 expression was not only …
Link: https://link.springer.com/article/10.1007/s00432-016-2218-0
Pleiotropic effects of DCLK1 in cancer and cancer stem cells
… Moreover, this review summarizes the effect of upregulated DCLK1 in several cancers … of DCLK1 by the use of small inhibitory molecules along with exosomes to target DCLK1, which …
Link: https://www.frontiersin.org/articles/10.3389/fmolb.2022.965730/full
DCLK1 Plays a Metastatic‐Promoting Role in Human Breast Cancer Cells
… to knock out DCLK1 in breast cancer cell line BT474… DCLK1 at a higher level, and stably overexpressed DCLK1 in another breast cancer cell line, T47D, that basically expresses DCLK1 …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/1061979
DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer
… of DCLK1 in colon cancer cells (65). In addition, crocetinic acid targets DCLK1 in cancer cells by inhibiting the hedgehog signaling pathway in pancreatic cancer cells (65). …
Link: https://www.spandidos-publications.com/10.3892/ol.2021.13111
Research progress of DCLK1 inhibitors as cancer therapeutics
… DCLK1 has the potential to inhibit cancer cell growth. Here, we review the evidence for DCLK1 as a prospective cancer … and mutational status in human cancers. We further discuss the …
Link: https://www.ingentaconnect.com/content/ben/cmc/2022/00000029/00000013/art00004
Dominant expression of DCLK1 in human pancreatic cancer stem cells accelerates tumor invasion and metastasis
… -lived DCLK1-positive cells and initiation of colon cancer [23]. … in mice that express DCLK1 contain morphologically and … pancreatic cancers, our studies revealed that DCLK1 is …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146564
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
… cancer In pancreatic and colorectal cancer cells, we have previously demonstrated that DCLK1 … siRNA-mediated knockdown of DCLK1 resulted in downregulation of let-7a downstream …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073940
Regulatory roles of Dclk1 in epithelial mesenchymal transition and cancer stem cells
… of cancer. We will highlight the functional activity of DCLK1 in supporting EMT and cancer … us to a better understanding of DCLK1 expression in cancer development and progression, …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913783/
Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: A systematic review and meta-analysis
… The discovery of DCLK1 potentials to distinguish colorectal CSCs from normal stem cells in CRC highlighted DCLK1 as a colon cancer-specific marker [11]. DCLK1 isolation, …
Link: https://link.springer.com/article/10.1186/s12935-022-02632-9
Retracted: DCLK1 promotes epithelial‐mesenchymal transition via the PI3K/Akt/NF‐κB pathway in colorectal cancer
… In this study of colorectal cancer (CRC), the authors found that an enzyme called DCLK1 … Finally, they found that silencing DCLK1 expression could inhibit metastasis of CRC cells in …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31232
DCLK1 autoinhibition and activation in tumorigenesis
… cancer-associated mutations occurring in the AID and elucidate how these mutations disrupt DCLK1 … DCLK1 kinase activity and provide insights into DCLK1-associated tumorigenesis. …
Link: https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00116-8
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer
… a progressive increase in Dclk1 expression during Kras … cell surface Dclk1, 20 we further quantified the number of Dclk1 + … Dclk1 expression, we isolated GFP Br /Dclk1 HI and GFP Br /…
Link: https://www.sciencedirect.com/science/article/pii/S001650851301411X
Targeting DCLK1 overcomes 5‐fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β‐catenin pathway‐mediated cancer stemness
… DCLK1 promoted cancer stemness, and DCLK1 positively regulated β-catenin signalling via CCAR1, we speculated that DCLK1 maintained cancer … (IWR-1-endo), DCLK1-mediated …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ctm2.743
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
… We induced overexpression of DCLK1 and inhibited DCLK1 (using inhibitors LRRK2-IN-1, … if DCLK1 and PD-L1 were strongly correlated. Mechanistically, we also explored if DCLK1 …
Link: https://www.sciencedirect.com/science/article/pii/S0024320519310781
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
… To consolidate our understanding of kinase activity dependent biological functions in cancer, a selective DCLK1 inhibitor, DCLK1-IN-1 was used. Initially, DCLK1-IN-1 10 was …
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9330537/
DCLK1 and its oncogenic functions: A promising therapeutic target for cancers
… assess the presence of DCLK1 protein in both … DCLK1 in diverse cancer types, including pancreatic cancer (PC) [9,10], renal cancer [11], colorectal cancer (CRC) [12,13], gastric cancer […
Link: https://www.sciencedirect.com/science/article/pii/S0024320523009293
Cancer stem cell marker DCLK1 correlates with tumorigenic immune infiltrates in the colon and gastric adenocarcinoma microenvironments
… cancers [41]. To explore the potential of using DCLK1 as a prognostic biomarker in GI cancers… High DCLK1 expression in tumor tissues predicted poor disease-specific survival (DSS) in …
Link: https://www.mdpi.com/2072-6694/12/2/274
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
… to target Dclk1 as a treatment strategy for colorectal cancer. … is less effective than DCLK1 knockdown in inhibiting cancer cells’ … Dclk1 can regulate multiple signaling pathways for cancer …
Link: https://link.springer.com/article/10.1186/s12943-017-0594-y
DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
… The high rate of cancer metastasis is a major issue in managing CRC. To unravel relevant … of DCLK1 in CRC, we conducted a series of assays with the DCLK1-silenced colon cancer …
Link: https://academic.oup.com/carcin/article-abstract/41/3/303/5575723
DCLK1 promotes malignant progression of breast cancer by regulating Wnt/β-Catenin signaling pathway.
… , we predict whether DCLK1 can be involved in the process of breast cancer cell proliferation and metastasis through the targeted regulation of the Wnt/β-catenin signal pathway. …
Link: https://www.europeanreview.org/wp/wp-content/uploads/9489-9498.pdf
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression
… results point toward cancer cell–intrinsic and –extrinsic functions for the DCLK1 kinase activity through the induction of cancer cell EMT leading to the mobilization of cancer cells into …
Link: https://www.science.org/doi/abs/10.1126/scisignal.abq4888
The essential role of DCLK1 in pathogenesis, diagnostic procedures and prognostic stratification of colorectal cancer
… to DCLK1 and DCLK1-target therapy by colorectal cancer, … Implications of DCLK1 Overexpression in Colorectal Cancer’. … with regard to DCLK1 in colorectal cancer, for formulating …
Link: https://ar.iiarjournals.org/content/39/6/2689.short
The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
… Citation 6 In this study, the methylation status of the DCLK1 promoter was investigated in several cancer cell lines, as well as in a large series of colorectal cancer and normal mucosa …
Link: https://www.tandfonline.com/doi/abs/10.4161/epi.27582
… of DCLK1‐AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
… In order to evaluate the effect of targeting DCLK1 in pancreatic cancer tumorigenesis, we … in renal cell cancer [21]. To determine its effects on pancreatic cancer tumorigenesis, we …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/6402925
Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
… sEVs isolated from DCLK1 overexpressing human GC cell line … using DCLK1-IN-1, a specific small molecule inhibitor of DCLK1, … Our findings highlight a specific role of DCLK1-kinase …
Link: https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/pmic.202000098
Tuft and cancer stem cell marker DCLK1: A new target to enhance anti-tumor immunity in the tumor microenvironment
… Importantly, clinically viable therapeutic means of targeting DCLK1 … DCLK1 in the tumor microenvironment, assess the potential for targeting DCLK1 in colon, pancreatic and renal cancer…
Link: https://www.mdpi.com/2072-6694/12/12/3801
DCLK1 immunoreactivity in colorectal neoplasia
… While these results confirm the increased immunohistochemical expression of DCLK1 in primary colorectal cancer, we also noted DCLK1 immunoreactivity in the histologically normal …
Link: https://www.tandfonline.com/doi/abs/10.2147/CEG.S30281
Roles of Dclk1 in the pathogenesis, diagnosis, prognosis and treatment of pancreatic cancer: A review
… This study suggested that the serum level of Dclk1 and Dclk1 + circulating tumor cells might play a potential role in the diagnosis of PC. Simultaneously, as mentioned above in our study…
Link: https://www.tandfonline.com/doi/abs/10.1080/17474124.2022.2020643
Alternative splice variants of DCLK1 mark cancer stem cells, promote self‐renewal and drug‐resistance, and can be targeted to inhibit tumorigenesis in kidney cancer
… We previously reported that DCLK1 is overexpressed in RCC compared to … DCLK1's expression in kidney cancers, we analyzed The Cancer Genome Atlas (TCGA) PAN-CANCER RNA-…
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31400