Functional implication of Dclk1 and Dclk1-expressing cells in cancer
… in understanding of the importance of Dclk1 function in tumorigenesis and cancer. … pancreatic cancer cells with reduced Dclk1 gene expression, and demonstrated that Dclk1 regulated …
Link: https://www.tandfonline.com/doi/abs/10.1080/21541248.2016.1208792
Pleiotropic effects of DCLK1 in cancer and cancer stem cells
… Moreover, this review summarizes the effect of upregulated DCLK1 in several cancers … of DCLK1 by the use of small inhibitory molecules along with exosomes to target DCLK1, which …
Link: https://www.frontiersin.org/articles/10.3389/fmolb.2022.965730/full
DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
… In this study, we investigated whether DCLK1 expression is altered in human colorectal cancer and its clinical significance. We observed that DCLK1 expression was not only …
Link: https://link.springer.com/article/10.1007/s00432-016-2218-0
DCLK1 and its interaction partners: An effective therapeutic target for colorectal cancer
… of DCLK1 in colon cancer cells (65). In addition, crocetinic acid targets DCLK1 in cancer cells by inhibiting the hedgehog signaling pathway in pancreatic cancer cells (65). …
Link: https://www.spandidos-publications.com/10.3892/ol.2021.13111
Regulatory roles of Dclk1 in epithelial mesenchymal transition and cancer stem cells
… of cancer. We will highlight the functional activity of DCLK1 in supporting EMT and cancer … us to a better understanding of DCLK1 expression in cancer development and progression, …
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4913783/
DCLK1 plays a metastatic‐promoting role in human breast cancer cells
… to knock out DCLK1 in breast cancer cell line BT474… DCLK1 at a higher level, and stably overexpressed DCLK1 in another breast cancer cell line, T47D, that basically expresses DCLK1 …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/1061979
Oncogenic functions and clinical significances of DCLK1 isoforms in colorectal cancer: A systematic review and meta-analysis
… -S isoform; and (iii) studies based on using antibodies could detect the sequence homology epitopes of both DCLK1-L and DCLK1-S isoforms, known as anti-DCLK1-L/S antibodies in …
Link: https://link.springer.com/article/10.1186/s12935-022-02632-9
DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target
… cancer progression. This review comprehensively examines the multifaceted roles of DCLK1 in GI cancers, … inflammatory states, and contributions to cancer progression and metastasis. …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.35365
Research progress of DCLK1 inhibitors as cancer therapeutics
… DCLK1 has the potential to inhibit cancer cell growth. Here, we review the evidence for DCLK1 as a prospective cancer … and mutational status in human cancers. We further discuss the …
Link: https://www.benthamdirect.com/content/journals/cmc/10.2174/0929867328666210709110721
DCLK1 Regulates Pluripotency and Angiogenic Factors via microRNA-Dependent Mechanisms in Pancreatic Cancer
… cancer In pancreatic and colorectal cancer cells, we have previously demonstrated that DCLK1 … siRNA-mediated knockdown of DCLK1 resulted in downregulation of let-7a downstream …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0073940
DCLK1 marks a morphologically distinct subpopulation of cells with stem cell properties in preinvasive pancreatic cancer
… DCLK1 marked a morphologically distinct and functionally unique population of pancreatic cancer–… Cells that expressed DCLK1 also expressed high levels of ATAT1, HES1, HEY1, …
Link: https://www.sciencedirect.com/science/article/pii/S001650851301411X
Role of DCLK1 in oncogenic signaling
… inflammation induced by dextran sodium sulfate is sufficient to initiate colon cancer in Dclk1-Cre/Apcflox/flox (Dclk1-Cre/Apcflox/flox transgenic mice featuring knocking out APC gene in …
Link: https://www.spandidos-publications.com/10.3892/ijo.2022.5427
Inhibition of DCLK1 down-regulates PD-L1 expression through Hippo pathway in human pancreatic cancer
… Therefore, we sought to understand if DCLK1 could positively regulate the expression of PD-L1 in pancreatic cancer cells. Furthermore, we examined if DCLK1 highly correlated with …
Link: https://www.sciencedirect.com/science/article/pii/S0024320519310781
Targeting DCLK1 overcomes 5‐fluorouracil resistance in colorectal cancer through inhibiting CCAR1/β‐catenin pathway‐mediated cancer stemness
… DCLK1 promoted cancer stemness, and DCLK1 positively regulated β-catenin signalling via CCAR1, we speculated that DCLK1 maintained cancer … (IWR-1-endo), DCLK1-mediated …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/ctm2.743
DCLK1 autoinhibition and activation in tumorigenesis
… Somatic DCLK1 cancer mutants display elevated kinase activity To explore the impact of DCLK1 somatic mutations in human cancers, we interrogated the COSMIC database and found …
Link: https://www.cell.com/the-innovation/fulltext/S2666-6758(21)00116-8
DCLK1 integrates induction of TRIB3, EMT, drug resistance and poor prognosis in colorectal cancer
… The high rate of cancer metastasis is a major issue in managing CRC. To unravel relevant … of DCLK1 in CRC, we conducted a series of assays with the DCLK1-silenced colon cancer …
Link: https://academic.oup.com/carcin/article-abstract/41/3/303/5575723
DCLK1 promotes malignant progression of breast cancer by regulating Wnt/β-Catenin signaling pathway.
… , we predict whether DCLK1 can be involved in the process of breast cancer cell proliferation and metastasis through the targeted regulation of the Wnt/β-catenin signal pathway. …
Link: https://www.europeanreview.org/wp/wp-content/uploads/9489-9498.pdf
Cancer stem cell marker DCLK1 correlates with tumorigenic immune infiltrates in the colon and gastric adenocarcinoma microenvironments
… cancers [41]. To explore the potential of using DCLK1 as a prognostic biomarker in GI cancers… High DCLK1 expression in tumor tissues predicted poor disease-specific survival (DSS) in …
Link: https://www.mdpi.com/2072-6694/12/2/274
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells
… to target Dclk1 as a treatment strategy for colorectal cancer. … is less effective than DCLK1 knockdown in inhibiting cancer cells’ … Dclk1 can regulate multiple signaling pathways for cancer …
Link: https://link.springer.com/article/10.1186/s12943-017-0594-y
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis
… To consolidate our understanding of kinase activity dependent biological functions in cancer, a selective DCLK1 inhibitor, DCLK1-IN-1 was used. Initially, DCLK1-IN-1 10 was …
Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC9330537/
The essential role of DCLK1 in pathogenesis, diagnostic procedures and prognostic stratification of colorectal cancer
… to DCLK1 and DCLK1-target therapy by colorectal cancer, … Implications of DCLK1 Overexpression in Colorectal Cancer’. … with regard to DCLK1 in colorectal cancer, for formulating …
Link: https://ar.iiarjournals.org/content/39/6/2689.short
Dominant expression of DCLK1 in human pancreatic cancer stem cells accelerates tumor invasion and metastasis
… -lived DCLK1-positive cells and initiation of colon cancer [23]. … in mice that express DCLK1 contain morphologically and … pancreatic cancers, our studies revealed that DCLK1 is …
Link: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146564
DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression
… results point toward cancer cell–intrinsic and –extrinsic functions for the DCLK1 kinase activity through the induction of cancer cell EMT leading to the mobilization of cancer cells into …
Link: https://www.science.org/doi/abs/10.1126/scisignal.abq4888
The recently suggested intestinal cancer stem cell marker DCLK1 is an epigenetic biomarker for colorectal cancer
… Citation 6 In this study, the methylation status of the DCLK1 promoter was investigated in several cancer cell lines, as well as in a large series of colorectal cancer and normal mucosa …
Link: https://www.tandfonline.com/doi/abs/10.4161/epi.27582
… of DCLK1‐AL Increases Tumor Cell Invasion, Drug Resistance, and KRAS Activation and Can Be Targeted to Inhibit Tumorigenesis in Pancreatic Cancer
… In order to evaluate the effect of targeting DCLK1 in pancreatic cancer tumorigenesis, we … in renal cell cancer [21]. To determine its effects on pancreatic cancer tumorigenesis, we …
Link: https://onlinelibrary.wiley.com/doi/abs/10.1155/2019/6402925
DCLK1 plays an important role in colorectal cancer tumorgenesis through the regulation of miR-200c
… Silencing of DCLK1 significantly inhibited cell migration, invasion, and sphere-forming … DCLK1 expression. Overall, our data demonstrated that DCLK1 plays an important role in cancer …
Link: https://www.sciencedirect.com/science/article/pii/S0753332218311685
Roles of Dclk1 in the pathogenesis, diagnosis, prognosis and treatment of pancreatic cancer: A review
… This study suggested that the serum level of Dclk1 and Dclk1 + circulating tumor cells might play a potential role in the diagnosis of PC. Simultaneously, as mentioned above in our study…
Link: https://www.tandfonline.com/doi/abs/10.1080/17474124.2022.2020643
Targeting DCLK1 attenuates tumor stemness and evokes antitumor immunity in triple-negative breast cancer by inhibiting IL-6/STAT3 signaling
… Here, we firstly explored the impacts of DCLK1 on tumor cells as well as their … DCLK1 expression. Our results disclosed that DCLK1 overexpression promoted, while knockout of DCLK1 …
Link: https://link.springer.com/article/10.1186/s13058-023-01642-3
Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA
… survival in response to curcumin; combination of DCLK1-siRNA and … DCLK1 in colon CSCs and highlight DCLK1 as a target to enhance antitumor properties of curcumin. Cancer …
Link: https://aacrjournals.org/cancerres/article-abstract/74/9/2487/599446
Enhancement of sensitivity to chemo/radiation therapy by using miR-15b against DCLK1 in colorectal cancer
… between DCLK1 expression in post-nRT rectal cancer and … role for DCLK1 in tumor initiation, the DCLK1+ and DCLK1− cells … Purified DCLK1+ but not DCLK1− cells were able to form …
Link: https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30438-7